collagen

October 18, 2017October 18, 2017

New Blocker of TGF-β1 Shows Promise as Potential Therapy for IPF Patients

Blocking TGF-β1 — a known signaling pathway involved in tissue fibrosis — by compounds called trihydrophenolics halted fibrosis development and tissue stiffness in animal models of pulmonary fibrosis, new research shows. The ... Read more

April 12, 2017April 13, 2017

Researchers Develop New Probe to Follow PF Progression, Treatment

Idiopathic Pulmonary Fibrosis, News

Researchers developed a new probe to use in positron emission tomography (PET) imaging that may help diagnose and monitor pulmonary fibrosis, according to a study. The probe, called 68Ga-CBP8, binds ... Read more

March 14, 2017March 14, 2017

Synairgen Reports Positive Data on Potential IPF Treatment

Idiopathic Pulmonary Fibrosis, News

Synairgen recently reported positive data from its ongoing work in partnership with Pharmaxis to develop a lysyl oxidase type 2 enzyme (LOXL2) inhibitor as a new treatment for idiopathic pulmonary fibrosis (IPF). Synairgen is ... Read more

March 7, 2017March 7, 2017

Treatment Seen to Lessen Fibrotic Scarring That Causes Lung Transplants to Fail

Bronchiolitis, COPD, Cystic Fibrosis, Idiopathic Pulmonary Fibrosis, News

Treatment may be able prevent the progressive accumulation of scar tissue (fibrosis) in newly transplanted lungs that eventually cause those organs to fail, researchers at the University of Michigan report. The study, “Autocrine lysophosphatidic ... Read more

April 29, 2016April 29, 2016

Fibrocell’s Gene Therapy for Localized Scleroderma Designated an Orphan Drug by FDA

News, Scleroderma

Fibrocell Science, Inc., recently announced that the U.S. Food and Drug Administration (FDA) has designated FCX-013 an orphan drug for the potential treatment of localized scleroderma, a chronic autoimmune disease in which the ... Read more

June 11, 2015November 9, 2015

New Potential Biomarkers for COPD Activity in Patients

COPD, News

A study recently published in the journal Respiratory Research proposes new potential biomarkers for chronic obstructive pulmonary disease (COPD) activity in patients. The study is entitled “Accelerated extracellular matrix turnover ... Read more

May 28, 2015November 5, 2015

Differences in Collagen Microstructure May Determine Treatment Response in Fibrotic Lung Diseases

Idiopathic Pulmonary Fibrosis, News

In a new study entitled “Second harmonic generation microscopy reveals altered collagen microstructure in usual interstitial pneumonia versus healthy lung,” the authors investigated differences in the structure of human lung tissues ... Read more