Guardant Health recently announced a partnership with the National Cancer Institute, a cancer research SWOG funded consortium, in order to identify the mechanisms of resistance and future treatment options to address patients suffering with non-small cell lung cancer (NSCLC).
The study, SWOG-1403, will utilize the company’s circulating tumor DNA test, the Guardant360, in order to examine if the combination EGFR blockade using the combination of cetuximab and afatinib is superior to afatinib used alone as a frontline treatment to address 600 patients recently newly diagnosed with EGFR-mutant NSCLC.
As part of the trial, investigators will assess patients’ blood upon enrollment in the study and again upon progression. Physicians will be blinded to the results at first until the time of progression at which researchers can use the findings to make relevant adjustments to therapy.
“NSCLC is an ideal tumor type to test this novel technology due to the known genomic complexity and evolution of this genomic landscape after therapy. In the case of patients with EGFR-mutated lung cancer, patients may fail first-line treatment due to the emergence of the T790M resistance mutation, which is one of the targets that Guardant360 will be used to detect,” said David Gandara who is the chair of the SWOG Lung Cancer Committee.
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